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Controlled Fluid Removal in Critical Ill Patients With Fluid Overload in the Intensive Care Unit.

NCT04180397 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 1000

Last updated 2025-02-06

No results posted yet for this study

Summary

This study evaluates the benefits and harms of goal directed fluid removal with furosemide versus placebo in critical ill adult patients with fluid overload in the intensive care unit. Half of the patients will receive furosemide and the other half placebo. The treatment will continue until the excess fluid is excreted.

Conditions

  • Fluid Overload

Interventions

DRUG

Furosemide

Furosemide 10 mg/ml for injection/infusion

DRUG

Isotonic saline

Isotonic saline used as placebo (injection/infusion)

Sponsors & Collaborators

  • University of Copenhagen

    collaborator OTHER

  • Copenhagen Trial Unit, Center for Clinical Intervention Research

    collaborator OTHER

  • Centre for Research in Intensive Care (CRIC)

    collaborator OTHER

  • Morten H. Bestle

    lead OTHER

Principal Investigators

  • Morten Bestle, MD · Department of Anaesthesiology and Intensive Care medicine Nordsjællands hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-08-17
Primary Completion
2026-12-31
Completion
2028-03-15

Countries

  • Australia
  • Denmark
  • Finland
  • Iceland
  • Netherlands
  • Norway
  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04180397 on ClinicalTrials.gov