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Reverse Electrical Remodeling of Native Conduction in Cardiac Resynchronization Therapy

NCT01924221 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 31

Last updated 2022-08-30

No results posted yet for this study

Summary

Cardiac resynchronization therapy with pacemaker alone, or in combination with a cardioverter-defibrillator, prolongs life and decreases risk of heart failure exacerbation in patients with low ejection fraction and wide QRS. Some patients achieve decrease in QRS duration 6 months after cardiac resynchronization therapy. Such phenomenon is called reverse electrical remodeling of native conduction. Retrospective analysis showed that reverse electrical remodeling of the native conduction after at least 6 months of CRT is associated with decreased rate of ventricular arrhythmias and better survival. This study is designed to study reverse electrical remodeling prospectively.

Conditions

Sponsors & Collaborators

Principal Investigators

  • Larisa Tereshchenko, MD, PhD · Johns Hopkins University

Eligibility

Min Age
18 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-12-31
Primary Completion
2022-08-01
Completion
2022-08-01

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01924221 on ClinicalTrials.gov