Frailty Assessment Before Cardiac Surgery & Transcatheter Interventions

Summary

Frailty is a state of decreased physiologic reserves and vulnerability to stressors. Several tools exist to measure frailty, some based on physical tests and others on questionnaires, yet there is no agreement on which tool to recommend. This multi-center prospective cohort study is aimed at comparing various frailty assessment tools to determine which best predicts death or major complications after cardiac surgery or transcatheter intervention. The population of interest is elderly patients with severe aortic stenosis undergoing surgical or transcatheter aortic valve replacement. The frailty assessment tools under investigation include composite frailty scales, physical performance tests, muscle mass, and biomarker expression. The overall objective is to improve our ability to predict risk by measuring frailty using the optimal tool in elderly cardiovascular patients.

Conditions

• Aortic Stenosis
• Cardiac Valve Replacement Complication
• Fragility

Sponsors & Collaborators

• Beth Israel Deaconess Medical Center

  collaborator OTHER

• Brigham and Women's Hospital

  collaborator OTHER

• Duke University

  collaborator OTHER

• Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal

  collaborator OTHER

• Massachusetts General Hospital

  collaborator OTHER

• McGill University Health Centre/Research Institute of the McGill University Health Centre

  collaborator OTHER

• McMaster University

  collaborator OTHER

• Montreal Heart Institute

  collaborator OTHER

• Royal Victoria Hospital, Canada

  collaborator OTHER

• St. Boniface Hospital

  collaborator OTHER

• Unity Health Toronto

  collaborator OTHER

• St. Paul's Hospital, Canada

  collaborator OTHER

• Ottawa Heart Institute Research Corporation

  collaborator OTHER

• Jewish General Hospital

  lead OTHER

Principal Investigators

• Jonathan Afilalo, MD MSc · Jewish General Hospital

Eligibility

Min Age

70 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2012-01-31

Primary Completion

2014-12-31

Completion

2016-03-31

Countries

• United States
• Canada
• France

Study Locations