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Circulating Exosomes As Potential Prognostic And Predictive Biomarkers In Advanced Gastric Cancer Patients ("EXO-PPP Study")

NCT01779583 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2015-03-25

No results posted yet for this study

Summary

Exosomes are formed by inward budding of late endosomes, producing multivesicular bodies (MVBs), and are released into the environment by fusion of the MVBs with the plasma membrane. It has been demonstrated that the content and function of exosomes depends on the originating cell and the conditions under which they are produced. Tumor exosome production, transfer and education of bone marrow cells supports tumor growth and metastasis.

In this prospective translational study, preclinical and clinical phases have been designed. On the first step, the main goal is to characterize the molecular profile of gastric cancer derived exosomes. This exosome biosignature may provide a useful diagnostic tool. As a second step, the study will evaluate the prognostic and predictive value of gastric cancer exosomes levels in plasma and kinetics in a prospectively recruited cohort of advanced gastric cancer patients during first-line chemotherapy.

Conditions

Sponsors & Collaborators

  • Centro Nacional de Investigaciones Oncologicas CARLOS III

    collaborator OTHER

  • Aragon Institute of Health Sciences

    collaborator OTHER

  • Hospital Miguel Servet

    lead OTHER

Principal Investigators

  • HECTOR PEINADO, PhD · Weill Medical College of Cornell University

  • PILAR MARTIN-DUQUE, PhD · Francisco de Vitoria´s University - Aragon Institute of Health Sciences

  • ROBERTO A PAZO-CID, MD · Aragon Institute of Health Sciences - Medical Oncology Department, Miguel Servet University Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-01-31
Primary Completion
2016-01-31

Countries

  • Spain

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01779583 on ClinicalTrials.gov