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Evaluation of Urinary Exosomes Presence From Clear Cell Renal Cell Carcinoma

NCT04053855 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2026-05-06

No results posted yet for this study

Summary

Clear cell renal cell carcinoma is diagnosed by imaging, sometimes associated with biopsy. This diagnosis is expensive, invasive and sometimes late. The development of a simple biological test for diagnosis is essential. Exosomes are 30 to 150 nm membrane vesicles secreted into the extracellular space by various living cells. These exosomes can be isolated from biological fluids, including urine. The recent study of urinary exosomes is a promising topic for analyzing tumor markers in urine. The investigator's goal is to develop a reliable technique for detecting tumor exosomes in urine in patients with clear cell renal cell carcinoma. The analysis of urinary exosomes could provide a new liquid biopsy tool for the early diagnosis of clear cell renal cell carcinoma.

Conditions

Interventions

BIOLOGICAL

Urinary sample

Urinary sample (100 ml) will be collected in the urology department to analysis urinary exosomes.

Sponsors & Collaborators

  • Centre Hospitalier Universitaire de Saint Etienne

    lead OTHER

Principal Investigators

  • Nicolas MOTTET, MD PhD · Centre Hospitalier Universitaire de Saint Etienne

  • Nora MALLOUK, PhD · UNIVERSITY SAINT-ETIENNE

  • Guorong LI, PhD · CHU DE SAINT-ETIENNE

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-01-29
Primary Completion
2026-08-01
Completion
2026-08-01

Countries

  • France

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04053855 on ClinicalTrials.gov