Research on the Accurate Diagnosis of Urinary Tract Tumors and the Development of Kits
NCT06193941 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 400
Last updated 2024-01-09
Summary
Bladder cancer is the second most prevalent urological malignancy worldwide, with a high incidence and poor patient prognosis. Achieving early diagnosis and intervention for bladder cancer is one of the most important ways to improve clinical management and patient prognosis. Tumor exosomes can be released into biological fluids at an early stage of a tumor, and many studies have shown that exosomal RNA can be used as a reliable biomarker to diagnose tumors in a non-invasive way. Based on the clinical needs for early diagnosis of bladder cancer, we aim to screen several early diagnostic markers with potential predictive value, establish an early diagnostic model for bladder cancer, and validate the validity and reliability of this diagnostic model through a large-scale clinical cohort to complement the diagnosis of early-stage cancers and to improve the rate of early diagnosis of cancer.
Conditions
Interventions
- DIAGNOSTIC_TEST
-
RT-qPCR
RT-qPCR
Sponsors & Collaborators
-
Zhongnan Hospital
lead OTHER
Principal Investigators
-
Fubing Wang, Doctor · Wuhan University
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2023-06-01
- Primary Completion
- 2023-12-01
- Completion
- 2023-12-01
Countries
- China
Study Locations
More Related Trials
-
The Necessity of a Second Transurethral Resection in High-risk Non-muscle-invasive Bladder Cancer Patients With Negative Urine Biomarker After Initial Transurethral Resection
NCT06287541 ·Status: RECRUITING ·Phase: NA
-
A Study Comparing the Necessity of a Second Transurethral Resection in High-Risk Non-Muscle-Invasive Bladder Cancer Patients With Negative Results From Post-Initial Resection Urine Genome-Wide Low-Depth Sequencing
NCT07036731 ·Status: RECRUITING ·Phase: NA
-
The Role of Universal Cancer Only Marker SIX6 in Diagnosing Non-Muscle Invasive Bladder Cancer
NCT07252297 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
The Prognostic Impact of Tumor Location in Non-Muscle-Invasive Bladder Cancer Patients
NCT06245759 ·Status: RECRUITING
-
Medical Imaging in Bladder Tumors by MRI
NCT06033040 ·Status: RECRUITING
-
Study of Disitamab Vedotin Combined With Gemcitabine in Neoadjuvant Treatment of Urothelial Carcinoma
NCT05723991 ·Status: UNKNOWN ·Phase: PHASE4
-
Establishment and Validation of an Early Diagnostic Model for Bladder Cancer Based on Serum and Urine Metabolomics
NCT04966962 ·Status: UNKNOWN
-
Analyzing the Urine During BCG Instillation in Bladder Cancer Patients for Disease Followup
NCT06153849 ·Status: NOT_YET_RECRUITING
-
A Prospective, Multicenter Cohort Study of Urinary Exosome lncRNAs for Preoperative Diagnosis of Lymphatic Metastasis in Patients With Bladder Cancer
NCT05270174 ·Status: UNKNOWN
-
Ultrasound Contrast-Enhanced Accurate Diagnosis of Preoperative Staging of Bladder Cancer
NCT06775977 ·Status: RECRUITING
-
Collecting and Studying Blood and Tissue Samples From Patients With Locally Recurrent or Metastatic Prostate or Bladder/Urothelial Cancer
NCT01050504 ·Status: RECRUITING
-
A Multicenter Prospective Cohort Study on Monitoring Recurrence of Urothelial Carcinoma Based on Detection of Urinary Microscopic Residual Disease (MRD)
NCT06991868 ·Status: RECRUITING
-
Comparative Study of Hexvix Blue Light Cystoscopy and White Light Cystoscopy in the Detection of Bladder Cancer
NCT05600322 ·Status: COMPLETED ·Phase: PHASE3
-
Longitudinal Bladder Cancer Study for Tumour Recurrence
NCT05080998 ·Status: RECRUITING
-
A Prospective, Multi-centre, Single-blinded Study of UroCAD for Urothelial Carcinoma Diagnosis and Follow-up
NCT04432909 ·Status: UNKNOWN
-
The Role of mRNA-based Urine Test (Xpert Bladder Cancer Monitor) in Predicting the Need for Second Look Biopsy After Transurethral Resection of Non Muscle-invasive Bladder Tumor.
NCT04603612 ·Status: COMPLETED ·Phase: NA
-
Whole-slide Image and CT Radiomics Based Deep Learning System for Prognostication Prediction in Bladder Cancer
NCT06389019 ·Status: RECRUITING
-
An Open-label, Single-arm, Multicenter Phase II Clinical Study: Evaluating RC48-ADC Combined With Triplizumab in the Neoadjuvant Treatment of Her2-positive Muscle-invasive Bladder Cancer
NCT05356351 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Circulating and Urine Tumor DNA Dynamics Predict Minimal Residual Disease and Recurrence Risk in Locally Advanced Upper Tract Urothelial Carcinoma
NCT05595408 ·Status: RECRUITING
-
Microscopic-spectroscopic Examination for Urothelial Tissue Characterization
NCT04310813 ·Status: COMPLETED
-
Clinical Study of Neoadjuvant Therapy Outcome Prediction of Muscle-invasive Bladder Cancer Based on PTC Drug Sensitivity Detection
NCT05767528 ·Status: UNKNOWN
-
Microbiota in Urine and Urothelium Can be a Factor for Induction of Urinary Bladder Cancer. The Study Will Examine Urine and Bladder Cancer Tissues From Male Patients and Urine of Controls Using Whole Genomic Sequencing Techniques and 16S rRNA. The Aim is to Elucidate Role of Microbiota in Bladder
NCT06289283 ·Status: ACTIVE_NOT_RECRUITING
-
Development of Multiphasic CT-based Delta-Radiomics Model for Predicting Postoperative Recurrence Risk in Bladder Cancer
NCT07251946 ·Status: COMPLETED
-
Guiding Value of Urinary Tumor DNA Testing in Cystoscopy for High-Risk/Very High-Risk Non-Muscle-Invasive Bladder Cancer
NCT07180212 ·Status: RECRUITING ·Phase: NA
-
Characterizing the Microvascular Environment of Bladder Cancer With Super-Resolution Ultrasound Localization Microscopy
NCT06986304 ·Status: RECRUITING