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Inspiratory Effort-Targeted Pressure Support Ventilation (IT-PSV) Trial

NCT06526598 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 619

Last updated 2026-01-21

No results posted yet for this study

Summary

The Inspiratory effort-Targeted Pressure Support Ventilation (IT-PSV) is a cluster randomized controlled trial. Its main aim is to determine whether an inspiratory effort-targeted pressure support setting strategy, compared to the traditional tidal volume and respiratory rate target, can improve clinical outcomes in adult participants undergoing pressure support ventilation.

The investigators propose a physiological-oriented assisted ventilation management that, if found effective, could potentially change the clinical practice for mechanical ventilation.

Conditions

  • Critical Care
  • Acute Hypoxic Respiratory Failure
  • Ventilator-Induced Lung Injury

Interventions

PROCEDURE

PMI-targeted pressure support setting and adjustment

During PSV, the pressure support is set and adjusted to a PMI target between 0 and 2 cmH2O.

PROCEDURE

VT/RR-targeted pressure support setting and adjustment

During PSV, pressure support is set and adjusted according to a VT/RR target of VT between 6 and 8 ml/kg predicted body weight, RR between 20 and 35 breaths/min, and no signs of respiratory distress.

Sponsors & Collaborators

  • Capital Medical University

    lead OTHER

Principal Investigators

  • Jian-Xin Zhou, MD · Capital Medical University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-01-19
Primary Completion
2027-01-31
Completion
2027-02-28

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06526598 on ClinicalTrials.gov