Electroencephalography-based Precise Repetitive Transcranial Magnetic Stimulation Treatment

Summary

This study will focus on the hypothesis that repetitive transcranial magnetic stimulation (TMS) based on EEG personalized modulation may be more effective in promoting symptomatic relief of major depressive disorder (MDD), and will rely on the platform of neuroimaging and function brain imaging of Shanghai Mental Health Center (SMHC), an authoritative institution in the field of mental health. We will eventually facilitate optimization of physical therapy for major depressive disorder (MDD).

Conditions

• Major Depressive Disorder (MDD)

Interventions

DEVICE

Individualized alpha frequency Transcranial Magnetic Stimulation (αTMS) Treatment

The target site for alpha frequency Transcranial Magnetic Stimulation (αTMS) was identified based on alterations in alpha band spectral connectivity, which were measured using four frontal electroencephalography (EEG) channels (F1, F3, F5, FC3) subsequent to 10Hz transcranial magnetic stimulation (TMS). Alpha band spectral connectivity refers to the degree of similarity between the spectral waveforms of the alpha band across channels. The alpha frequency stimulation rate was defined as the highest spectral peak within the alpha band ranging from 7 to 13 Hz of the target channel. Each treatment cycle consisted of 20 daily sessions over a 4-week span, and stimulation was administered for 2 seconds every minute for a total duration of 20 minutes at 80% of the individual's motor threshold.

DEVICE

10Hz-frequency TMS treatment over the left dorsolateral prefrontal cortex (DLPFC)

Prefrontal Transcranial Magnetic Stimulation (TMS) therapy repeated daily over 4 weeks (20 sessions) is US Food and Drug Administration (FDA) approved for treating Major Depressive Disorder in adults who have not responded to prior antidepressant medications. The strongest evidence supports high-frequency treatment over the left dorsolateral prefrontal cortex (DLPFC). The common stimulation frequency is 10Hz. It is usually applied for a duration of 4 weeks, 5 days a week.

Sponsors & Collaborators

• National Natural Science Foundation of China

  collaborator OTHER_GOV

• Shanghai Municipal Science and Technology Commission

  collaborator OTHER_GOV

• Shanghai Jiao Tong University School of Medicine

  collaborator OTHER

• Shanghai Mental Health Center

  lead OTHER

Principal Investigators

• TianHong Zhang, Doctor · Shanghai Mental Health Center

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

16 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-05-27

Primary Completion

2026-05-31

Completion

2026-05-31

Countries

• China

Study Locations