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Alcohol Inhibits Drug Metabolism by Carboxylesterases

NCT01708369 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 19

Last updated 2012-10-16

No results posted yet for this study

Summary

The purpose of this study is to determine if alcohol is able the affect the body's ability to eliminate two commonly used medication, oseltamivir and aspirin. We hypothesize that drinking alcohol may reduce the body's ability to break down these two medications along with many others.This could affect the amount of drug in the blood which could impact how well these drugs work and whether patients have side effects.

Conditions

  • Drug Interactions

Interventions

DRUG

Placebo

Orange juice administered 15 minutes before subjects take oseltamivir or aspirin

DRUG

Ethanol

Ethanol will be mixed with orange juice and subjects will drink the mixture 15 minutes before receiving oseltamivir or aspirin

DRUG

Oseltamivir

Oseltamivir 150 mg orally

DRUG

Aspirin

Aspirin 650 mg orally will be given

Sponsors & Collaborators

  • University of Tennessee

    lead OTHER

Principal Investigators

  • Robert B Parker, PharmD · University of Tennessee

  • Steven C Laizure, PharmD · University of Tennessee

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
21 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-02-29
Primary Completion
2012-05-31
Completion
2012-05-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01708369 on ClinicalTrials.gov