Project 1, Study 1: Investigating the Impact of Nicotine Using Spectrum Cigarettes

Summary

Project 1, Study 1 will evaluate the relationship between nicotine yield of very low nicotine content cigarettes and cigarettes smoked per day, nicotine exposure, discomfort/dysfunction, other health-related behaviors, nicotine/tobacco dependence, biomarkers of tobacco exposure, intention to quit, compensatory smoking, other tobacco use, cigarette characteristics, cognitive function, cardiovascular function, and perceived risk. We will also consider differences between conditions in compliance with product use.

Conditions

• Tobacco Dependence

Interventions

OTHER

very low nicotine content cigarettes

Sponsors & Collaborators

• National Institute on Drug Abuse (NIDA)

  collaborator NIH

• Masonic Cancer Center, University of Minnesota

  collaborator OTHER

• Brown University

  collaborator OTHER

• Johns Hopkins University

  collaborator OTHER

• University of California, San Francisco

  collaborator OTHER

• M.D. Anderson Cancer Center

  collaborator OTHER

• University of Pennsylvania

  collaborator OTHER

• Duke University

  collaborator OTHER

• H. Lee Moffitt Cancer Center and Research Institute

  collaborator OTHER

• University of Minnesota

  collaborator OTHER

• Wake Forest University Health Sciences

  lead OTHER

Principal Investigators

• Eric C Donny, PhD · University of Pittsburgh

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2013-06-30

Primary Completion

2014-07-31

Completion

2014-07-31

Countries

• United States

Study Locations