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Project 2: Strategies for Reducing Nicotine Content in Cigarettes

NCT02139930 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 1250

Last updated 2018-08-15

No results posted yet for this study

Summary

The main goal of this project is to compare two different approaches to reducing levels of nicotine in cigarettes: an immediate reduction in nicotine content in cigarettes to non-addictive levels or a gradual reduction in nicotine content in cigarettes to non-addictive levels. These two approaches will then be contrasted to a group that continues to smoke cigarettes with nicotine content similar to conventional cigarettes.

Conditions

  • Nicotine Dependence
  • Tobacco Smoking

Interventions

BEHAVIORAL

Normal Nicotine Control Group

Participants will smoke experimental cigarettes for a period of 20-weeks.

BEHAVIORAL

Immediate Nicotine Reduction Group

Participants will smoke experimental cigarettes for a period of 20-weeks.

BEHAVIORAL

Gradual Nicotine Reduction Group

Participants will smoke experimental cigarettes for a period of 20-weeks.

Sponsors & Collaborators

  • National Institute on Drug Abuse (NIDA)

    collaborator NIH

  • Wake Forest University Health Sciences

    lead OTHER

Principal Investigators

  • Eric Donny, PhD · University of Pittsburgh

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-09-30
Primary Completion
2017-03-31
Completion
2017-03-14

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02139930 on ClinicalTrials.gov