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Effect of Cannabis on Cigarette Use Behavior

NCT06609083 · Status: RECRUITING · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2026-01-16

No results posted yet for this study

Summary

The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of cigarettes. The study's goals are to test demand for cigarettes, tobacco craving, affect, heart rate, blood pressure, expired breath carbon monoxide, and cognitive performance. Researchers will compare multiple doses of THC and a placebo in participants who smoke cigarettes and either smoke or vape THC in the laboratory.

Conditions

  • Cannabis Use
  • Tobacco Use
  • Cigarette Smoking

Interventions

DRUG

THC 30mg

High dose of THC (30 mg)

DRUG

THC 5mg

Low dose of THC (5 mg)

DRUG

THC 0mg

Placebo dose of THC (0 mg)

DRUG

Cigarette Full Nicotine

Full nicotine cigarette

DRUG

Cigarette Reduced Nicotine

Reduced nicotine cigarette

Sponsors & Collaborators

Principal Investigators

  • Dustin Lee, PhD · Johns Hopkins School of Medicine

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
FACTORIAL

Eligibility

Min Age
21 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-01-22
Primary Completion
2029-04-01
Completion
2029-10-01
FDA Drug
Yes

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06609083 on ClinicalTrials.gov