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Low Nicotine Cigarettes, Smoking, and Chronic Pain

NCT05032755 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2025-08-29

Study results available
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Summary

The purpose of this study is to evaluate the effects of switching to very low nicotine content (VLNC) cigarettes versus normal nicotine content (NNC) cigarettes on experiences with craving, withdrawal, and pain among individuals with chronic back pain who smoke cigarettes daily.

Conditions

Interventions

OTHER

SPECTRUM NRC 102/103 investigational cigarettes

Very low nicotine content (nonmenthol/menthol) SPECTRUM investigational cigarettes

OTHER

SPECTRUM NRC 600/601 investigational cigarettes

Normal nicotine content (nonmenthol/menthol) SPECTRUM investigational cigarettes

Sponsors & Collaborators

  • National Institute on Drug Abuse (NIDA)

    collaborator NIH

  • Duke University

    lead OTHER

Principal Investigators

  • Maggie Sweitzer · Duke University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
21 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-06-23
Primary Completion
2024-07-04
Completion
2024-07-04

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05032755 on ClinicalTrials.gov