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Wean Obese Study : Determination of the Optimal Spontaneous Breathing Trial for Obese Patient

NCT01616901 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 31

Last updated 2013-05-31

No results posted yet for this study

Summary

The decision to extubate a patient after acute respiratory failure is based on clinical observation and measurement of pulmonary mechanics. Current extubation criteria(tidal volume, respiratory frequency...) lack of specificity. The best way to evaluate and predict patients breathing abilities after extubation is to challenge him to a spontaneous breathing trial (SBT) with endotracheal tube in place immediately before extubation to predict the patient's ability to breathe spontaneously after extubation. The intention is to approximate, while the patient is still intubated, the work of breathing that will be required of the patient after extubation. Different approaches of ventilatory settings are currently used for the preextubation SBT, whether pressure support ventilation (PSV), continuous positive airway pressure (CPAP), or spontaneous ventilation through an endotracheal tube (T piece), all supported by literature with different benefits. To the investigators knowledge, few studies define which mode of ventilation most closely approximates the work of breathing during spontaneous respiration after extubation, and none have studied a specific population of obese patient in respiratory weaning. The main objective of the investigators study is to determine, between five different SBT, which one is the best to approximate the work of breathing of obese patient after extubation.

Conditions

  • Obesity
  • Respiratory Failure
  • PSV 7cmH2O PEEP 7cmH2O
  • PSV 7 cmH2O PEEP 0 cmH20
  • CPAP 7 cmH2O
  • PSV 0 cmH20 PEEP 0 cmH2O
  • T-Tube
  • Post-extubation in Spontaneous Breathing and/or in NIV

Interventions

PROCEDURE

Spontaneous breathing trial

5 spontaneous breathing trial will be tested by the patients in the same order : * 7 cm H2O continuous positive airway pressure * T piece * 7 cmH2O of pressure support * 0 cmH20 of pressure support * 7 cm H2O pressure support ventilation with 7 cmH20 of end expiratory pressure.

Sponsors & Collaborators

  • University Hospital, Montpellier

    lead OTHER

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-04-30
Primary Completion
2013-04-30
Completion
2013-04-30

Countries

  • France

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01616901 on ClinicalTrials.gov