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Role of Infected Blood Dendritic Cells in Heart Disease Risk

NCT01568944 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 18

Last updated 2020-05-12

Study results available
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Summary

The investigators hypothesize that blood dendritic cells harbor pathogens from the oral cavity in chronic periodontitis and disseminate these pathogens to atherosclerotic plaques.

Conditions

  • Chronic Periodontitis

Interventions

DRUG

Oral Antibiotic and Oral Rinse

PO Amoxicillin in 500 mg / Metronidazole 250 mg of each TID for 8 days plus 2 ounces of 0.12% chlorhexidine mouthrinse used BID

PROCEDURE

Standard Treatment

Full mouth scaling and root planing using hand instrumentation (curettes) and ultrasonic scalers

Sponsors & Collaborators

  • National Institute of Dental and Craniofacial Research (NIDCR)

    collaborator NIH

  • Augusta University

    lead OTHER

Principal Investigators

  • Christopher Cutler, DDS · GHSU-College of Dental Medicine

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-03-31
Primary Completion
2014-09-30
Completion
2014-09-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01568944 on ClinicalTrials.gov