Periodontitis and Cardiovascular Events or "PAVE"

Summary

The purpose of this study is to determine if treating periodontal infections (gum problems) will lead to fewer heart problems in patients at high risk for cardiovascular disease.

Conditions

• Cardiovascular Disease
• Coronary Heart Disease
• Myocardial Infarction
• Cerebrovascular Accident

Interventions

PROCEDURE

Periodontal Treatment: SRP

Scaling and root planing. Subgingival tissue removal. Fluorides as needed. Oral hygiene instructions. Oral hygiene instructions.

PROCEDURE

Referral

Sponsors & Collaborators

• National Institute of Dental and Craniofacial Research (NIDCR)

  collaborator NIH

• University at Buffalo

  lead OTHER

Principal Investigators

• Sara G Grossi, DDS, MS · University at Buffalo

• Thomas E van Dyke, DDS,MS · Goldman School of Dental Medicine, Boston, MA

• John C Gunsolley, DDS,MS · University of Maryland, Dept. of Periodontics, Baltimore, MD

• James D Beck, Ph.D · University of NC, School of Dentistry, Chapel Hill, NC

• Lloyd E Chambless, PhD, · University of NC, Dept. of Biostatistics, Chapel Hill, NC

• Steven Offenbacher, DDS,PhD,MMSc · University of NC, Comprehensive Cntr. for Inflammatory Diseases, Chapel Hill, NC

• Theresa Madden, DDS, PhD · Oregon Health and Science University, Portland, OR

• Gerardo Maupome, PhD · Kaiser-Permanente Center for Health Research, Portland, OR

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2003-01-31

Primary Completion

2005-06-30

Completion

2005-06-30

Countries

• United States

Study Locations