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Nephron Sparing Renal Surgery and Total Nephrectomy

NCT02646293 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2024-01-30

No results posted yet for this study

Summary

The incidence of the diagnosis of renal cell carcinoma has increased during the past two decades because of the detection of small renal tumours that occur incidentally because of increased use of CT-scanning (1,2). Postoperative renal insufficiency was a significant independent predictor of overall and cardiovascular specific survival (3). "Nephron-sparing" surgical techniques are now preferred for small tumor masses and laparoscopic intervention is replacing open surgery at centers that master this technique. This is an area of priority within the Regions of Zaeland and Southern Denmark.

The primary endpoint is:

The early plasma (5 days) \[NT-proBNP\] response predicts long-term total renal function and function of the remaining kidney.

The second endpoint:

Plasma \[NT-proBNP\] increases acutely after partial nephrectomy and the change reflects the renal mass reduction.

Chronic blood pressure change is inversely related to plasma \[BNP\].

Conditions

Sponsors & Collaborators

  • Zealand University Hospital

    lead OTHER

Principal Investigators

  • Nessn Azawi, M.D. · Roskilde University Hospital

Eligibility

Min Age
25 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-05-31
Primary Completion
2022-02-13
Completion
2022-12-31

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02646293 on ClinicalTrials.gov