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PICU Transfusion Study: Harmful Effects of Red Blood Cell Transfusions

NCT02087553 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2019-03-27

No results posted yet for this study

Summary

The investigators hypothesize that the storage-damaged red cells are responsible for some of the adverse effects of transfusion. In this observational study, the investigators will measure various laboratory parameters both before and after transfusion in a pediatric intensive care unit to determine at what duration of storage is there laboratory evidence of refrigerator storage damage.

The investigators hypothesize that increasing storage time of packed red blood cells (PRBCs) transfused will be associated with increasing non-transferrin-bound iron (NTBI), pro-inflammatory cytokine concentrations, and enhanced microbial growth in vitro in pediatric patients.

Conditions

  • Iron, Abnormal Blood Level

Interventions

BIOLOGICAL

Transfusion of red blood cells

(non-experimental) PRBC transfusion

BIOLOGICAL

Infusion of albumin/saline

(non-experimental) albumin/saline infusion

Sponsors & Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • Columbia University

    lead OTHER

Principal Investigators

  • Eldad A Hod, MD · Columbia University

Eligibility

Max Age
21 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-12-31
Primary Completion
2014-10-31
Completion
2018-12-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02087553 on ClinicalTrials.gov