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New Markers to Measure Clotting in Patients With the Obstructive Sleep Apnoea Hypopnoea Syndrome

NCT01525160 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 66

Last updated 2014-04-10

No results posted yet for this study

Summary

Obstructive Sleep Apnoea Hypopnoea Syndrome(OSAHS)affects at least 4% of males and 2% of females.

OSAHS is the combination of excessive daytime sleepiness, snoring and apnoeas (stopping breathing at night). As well as affecting tiredness, mood, concentration and quality of life - there is growing concern that it can increase the risk of high blood pressure, heart problems, strokes and thromboses (clots in the veins).

It appears that OSAHS may affect the thickness of the blood and cause it to clot more easily it also causes damage to the lining of the blood vessels (endothelial injury). These effects seem independent of other risk factors such as obesity, smoking, family history of clots etc.

The investigators are testing new biomarkers: gel point and fractal dimension developed at the Swansea University to measure the 'clotting' of the blood in people with OSAHS and a similar group of people who snore and who are sleepy but do not have OSAHS on sleep studies (Controls) Also markers of vascular inflammation are being measured.

Conditions

  • Obstructive Sleep Apnoea Hypopnoea Syndrome
  • Biomarkers of Fibrin Clot Structure
  • Biomarkers of Vascular Endothelial Injury

Sponsors & Collaborators

  • National Institute for Health Research, United Kingdom

    collaborator OTHER_GOV

  • Abertawe Bro Morgannwg University NHS Trust

    collaborator OTHER_GOV

  • Swansea University

    collaborator OTHER

  • Hywel Dda Health Board

    lead OTHER

Principal Investigators

  • Kier Lewis, MD MBChB · Prince Philip Hospital

  • Phillip A Evans, Prof · Morriston Hospital

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-10-31
Primary Completion
2012-09-30
Completion
2013-03-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01525160 on ClinicalTrials.gov