MedTrace Logo

Diet Oil Induced Stimulation of GLP-1

NCT01453842 · Status: COMPLETED · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2014-12-02

No results posted yet for this study

Summary

Activation of G protein-coupled receptor GPR119 stimulates glucagon-like peptide-1 (GLP-1)release from the intestinal L-cells. Previously, administration of 2-oleyl-glycerol (2-OG) to humans significantly increased plasma GLP-1. In the present study we want to test the effect in patients with type 2 diabetes. The hypothesis is that we will expect to find a significant increased plasma GLP-1 following a meal containing of 2-OG when compared to meals containing of olive oil or carbohydrates alone.

Conditions

Interventions

DIETARY_SUPPLEMENT

Diet oil

Carrot and diet oil (containing 2-OG) and 1½ g of paracetamol

DIETARY_SUPPLEMENT

Olive oil

Carrot and olive oil and 1½ g of paracetamol

DIETARY_SUPPLEMENT

Carrot

Carrot and 1½ g of paracetamol

Sponsors & Collaborators

  • University of Copenhagen

    lead OTHER

Principal Investigators

  • Katrine B Hansen, MD · University of openhagen

  • Jens J Holst, Professor · University of Copenhagen

  • Harald S Hansen, Professor · University of Copenhagen

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-03-31
Primary Completion
2011-12-31
Completion
2012-03-31

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01453842 on ClinicalTrials.gov