Adipokines in Obese Adolescents With Insulin Resistance

Summary

The purpose of this study is to compare serum concentrations of inflammatory cytokines, interleukin 6 (IL-6), High-sensitivity C-reactive protein (hs-CRP), adiponectin, and tumour necrosis factor alpha (TNFα), before and after three months treatment with metformin in obese adolescents with insulin resistance (IR).

Conditions

• Obesity

Interventions

DRUG

Metformin

Tablet of 500 mg metformin, oral every 12 hours (total metformin dose of 1 g/day) for 3 months.

DRUG

Placebo

Tablet of 500 mg oral placebo every 12 hours for 3 months.

Sponsors & Collaborators

• Hospital Infantil de Mexico Federico Gomez

  collaborator OTHER

• Hospital Regional de Alta Especialidad del Bajio

  lead OTHER

Principal Investigators

• Maria L Evia-Viscarra, M.D. · Hospital Regional de Alta Especialidad del Bajio

• Edel R Rodea-Montero, Statistician · Hospital Regional de Alta Especialidad del Bajio

• Evelia Apolinar-Jiménez, Nutrition · Hospital Regional de Alta Especialidad del Bajio

• Leticia M García-Morales, M.D. · Hospital Infantil de Mexico Federico Gomez

• Constanza Leaños-Pérez, M.D. · Hospital Infantil de Mexico Federico Gomez

• Mireya Figueroa-Barrón, Chemestry · Hospital Infantil de Mexico Federico Gomez

• Dolores Sánchez-Fierros, Chemestry · Hospital Infantil de Mexico Federico Gomez

• Nathalie Muñoz-Noriega, Nutrition · Hospital Regional de Alta Especialidad del Bajio

• Juan G Reyes-García, M.D. · Escuela Superior de Medicina del IPN

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

9 Years

Max Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2007-01-31

Primary Completion

2009-12-31

Completion

2010-03-31

Countries

• Mexico

Study Locations