Safety and Efficacy of Procalcitonin Guided Antibiotic Therapy in Adult Intensive Care Units (ICU's)

Summary

This is a randomized controlled trial comparing standard-of-care therapy of infections in critically ill patients with a procalcitonin-guided approach evaluating efficacy (antibiotics consumption) and safety (mortality).

Conditions

• Sepsis
• Severe Sepsis
• Septic Shock

Interventions

OTHER

procalcitonin-guidance

If procalcitonin levels decrease to predefined levels, antibiotic therapy will be discontinued.

Sponsors & Collaborators

• UMC Utrecht

  collaborator OTHER

• Elisabeth-TweeSteden Ziekenhuis

  collaborator OTHER

• Diakonessenhuis, Utrecht

  collaborator OTHER

• Isala

  collaborator OTHER

• Atrium Medical Center

  collaborator OTHER

• Dijklander Ziekenhuis

  collaborator OTHER

• Bronovo Hospital

  collaborator OTHER

• Medical Center Haaglanden

  collaborator OTHER

• Slotervaart Hospital

  collaborator OTHER

• University of Groningen

  collaborator OTHER

• Martini Hospital Groningen

  collaborator OTHER

• Canisius-Wilhelmina Hospital

  collaborator OTHER

• Medisch Spectrum Twente

  collaborator OTHER

• St. Lucas Andreas Ziekenhuis Hospital

  collaborator OTHER

• Amsterdam UMC, location VUmc

  lead OTHER

Principal Investigators

• Evelien de Jong, MSc · Amsterdam UMC, location VUmc

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2009-11-30

Primary Completion

2014-08-31

Completion

2014-08-31

Countries

• Netherlands

Study Locations