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Use of Inflammatory Biomarkers to Guide Antibiotic Therapy in Patients With Severe Infections

NCT00934011 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 94

Last updated 2016-02-03

No results posted yet for this study

Summary

In this study the investigators aim to test if C-reactive protein (CRP)or procalcitonin(PCT) - guided strategy allows to reduce the antibiotic use in patients wiht severe sepsis and septic shock. Therefore, the safety of this intervention will be carefully measured.

Conditions

  • Severe Sepsis
  • Septic Shock

Interventions

OTHER

C-reactive protein guided antibiotic therapy

plasma CRP measurement to guide the duration of antibiotic therapy

OTHER

Procalcitonin guided antibiotic therapy

plasma PCT measurement to guide the duration of antibiotic therapy

Sponsors & Collaborators

  • Fundação de Amparo à Pesquisa do estado de Minas Gerais

    collaborator OTHER

  • Federal University of Minas Gerais

    lead OTHER

Principal Investigators

  • Vandack A Nobre, PhD · Medical School of the Federal University of Minas Gerais

  • Carolina F Oliveira, MD · Idem

  • Fernando A Botoni, PhD · Idem

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-09-30
Primary Completion
2012-05-31
Completion
2012-05-31

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00934011 on ClinicalTrials.gov