MedTrace Logo

Asymptomatic Carotid Stenosis: Cognitive Function and Plaque Correlates

NCT01353196 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 170

Last updated 2019-07-24

Study results available
· View outcomes & findings →

Summary

Carotid artery plaques are known to cause stroke. Cognitive impairment is an insidious but poorly understood problem in patients with carotid plaques. Cognitive function describes how people perform mental processes such as thinking, learning and problem solving. Asymptomatic carotid plaques may affect 1 million Veterans who may be at risk for cognitive impairment. In this study, the investigators will uncover the extent of cognitive impairment in Veterans with carotid stenosis who are currently labeled "asymptomatic". Programs to prevent or mitigate cognitive impairment will depend on identifying the mechanisms by which this occurs. The investigators will use sophisticated 3D imaging techniques developed by the group to measure the structure and composition of plaques, number of particles breaking off from them, blood levels of chemicals that could disrupt them, and blood flow restriction to the brain from them. This will help identify patients at risk for cognitive impairment who may benefit from preventative measures and improve selection of patients to decrease unnecessary surgical procedures.

Conditions

  • Cognitive Manifestations

Sponsors & Collaborators

  • VA Office of Research and Development

    lead FED

Principal Investigators

  • Brajesh K Lal, MD · Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-05-15
Primary Completion
2018-02-28
Completion
2018-02-28

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01353196 on ClinicalTrials.gov