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Brain Imaging in Elderly People and Individuals With Alzheimer's Disease

NCT00001917 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 150

Last updated 2008-03-04

No results posted yet for this study

Summary

The purpose of this study is to use brain imaging technology to study the effects of aging and Alzheimer's Disease (AD) on a specific type of brain receptor.

The brain is made up of cells called neurons. The neurons communicate with one another and secrete chemicals called neurotransmitters. The neurotransmitters bind to specific sites on other neurons called receptors. Acetylcholine (ACh) is a neurotransmitter that binds to ACh receptors. In both aging and AD, the number of neurons that secrete ACh decreases and the function of some ACh receptors changes. This study will use positron emission tomography (PET) scans of the brain to study the effects of age and AD on muscarinic type 2 \[M2\], a type of ACh receptor.

Participants in this study will be injected with a radioactive tracer (ligand \[F-18\] FP-TZTP) which binds to \[M2\] receptors. Participants will then undergo a PET scan in order for the density and function of \[M2\] receptors to be studied.

Conditions

Interventions

DRUG

O15

DRUG

[F-18] FP-TZTP

Sponsors & Collaborators

  • National Institute of Mental Health (NIMH)

    lead NIH

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
1999-04-30
Completion
2005-04-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00001917 on ClinicalTrials.gov