Re-irradiation of High Grade Gliomas: a Quality of Life Study

Summary

Patients with a high grade glioma have an increasing overall survival and progression free survival after initial treatment. Because of a better performance status these patients are more often eligible for re-treatment with for example radiotherapy. However, to date only a few prospective studies on re-irradiation of gliomas exist and very little is known about the effects of re-irradiation on quality of life and cognition. This trial is designed to longitudinally establish the effects of re-irradiation on quality of life, cognition and physical performance in patients with a high grade glioma. Based on the currently available information the investigators hypothesize that quality of life after re-irradiation can be kept stable until further tumour progression.

Conditions

• Anaplastic Astrocytoma
• Glioblastoma Multiforme
• Anaplastic Oligoastrocytoma

Interventions

OTHER

EORTC QLQ-C30

The EORTC QLQ-C30 is a questionnaire developed to assess the quality of life of cancer patients. It is supplemented by disease specific modules for e.g. Breast, Lung, Head \& Neck, Oesophageal, Ovarian, Gastric, Cervical cancer, Multiple Myeloma, Oesophago-Gastric, Prostate, Colorectal Liver Metastases, Colorectal and Brain cancer which are distributed from the EORTC Quality of Life Department. Other disease specific modules are under development but not yet validated.

OTHER

EORTC QLQ-BN20

The EORTC QLQ-C30 is a questionnaire developed to assess the quality of life of cancer patients. It is supplemented by disease specific modules for e.g. Breast, Lung, Head \& Neck, Oesophageal, Ovarian, Gastric, Cervical cancer, Multiple Myeloma, Oesophago-Gastric, Prostate, Colorectal Liver Metastases, Colorectal and Brain cancer which are distributed from the EORTC Quality of Life Department. Other disease specific modules are under development but not yet validated.

OTHER

Hopkins Verbal Learning Test-Revised (HVLT-R)

The HVLT-R is a cognitive test to assess verbal learning and memory.

OTHER

Stroop color-word test

The Stroop Color and Word Test is a brief five minute test which is used to assess brain dysfunction, cognition, and psychopathology.

OTHER

Controlled oral word association test (COWA)

The COWA is a measure of verbal fluency that requires expressive language and executive functions.

OTHER

Jamar hand dynamometer

The Jamar hand dynamometer is a screening instrument that is used to assess grip strength.

OTHER

EORTC QLQ- FA13

The Fatigue Questionnaire (QLQ-FA13) is a 13-item questionnaire to assess fatigue in patients with cancer. It is meant to be used in conjunction with the EORTC QLQ-C30

OTHER

Trail Making Test (TMT)

The TMT The Trail Making Test is a neuropsychological test of visual attention and task switching. It consists of two parts in which the subject is instructed to connect a set of 25 dots as fast as possible while still maintaining accuracy.

Sponsors & Collaborators

• Maastricht Radiation Oncology

  lead OTHER

Principal Investigators

• Brigitta Baumert, MD, MBA · Maastro Clinic, The Netherlands

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2013-03-31

Primary Completion

2015-03-31

Completion

2015-09-30

Countries

• Netherlands

Study Locations