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Rapid Infusion of Cold Normal Saline During CPR for Patients With Out-of-hospital Cardiac Arrest

NCT01173393 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 1220

Last updated 2015-01-22

No results posted yet for this study

Summary

That paramedic core cooling during CPR using a rapid infusion of ice-cold (4 degrees C) large-volume (30mL/kg) normal saline improves outcome at hospital discharge compared with standard care in patients with out-of-hospital cardiac arrest.

Conditions

  • Out-of-hospital Cardiac Arrest

Interventions

PROCEDURE

PARAMEDIC COOLING

For patients randomised to paramedic cooling: * LMA/ Intubation and ventilation with 100% oxygen * Measure temperature using tympanic probe and record * Paramedic cooling using infusion of 20mL/kg cold fluid via IV during CPR * If temperature \>34.5ºC, infuse further 10mL/kg stat * After ROSC, infuse further (max 2 litres) ice-cold saline * If shivering occurs post resuscitation and intubated, administer midazolam 2-5mg IV and pancuronium 8 mg.

Sponsors & Collaborators

  • Western Australian Ambulance Service

    collaborator UNKNOWN

  • South Australian Ambulance Service

    collaborator UNKNOWN

  • Ambulance Victoria

    lead OTHER_GOV

Principal Investigators

  • Stephen A Bernard, MD · Ambulance Victoria

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
SINGLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-07-31
Primary Completion
2014-12-31
Completion
2014-12-31

Countries

  • Australia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01173393 on ClinicalTrials.gov