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The Relationship Between Normal Saline Infusion and Acute Kidney Injury in Heat Stroke

NCT05921695 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 190

Last updated 2024-09-20

No results posted yet for this study

Summary

The goal of this clinical trial is to compare the effect of high chlorine solution such as normal saline and non-high chlorine solution such as sodium lactate ringer's solution on renal function in patients with heat stroke. The main question it aims to answer is whether limiting the amount of normal saline infusion during emergency department can lower the incidence of acute kidney injury and mortality in patients with heat stroke.

Participants will receive a free normal saline infusion during the emergency department according to the study design, or a restricted normal saline infusion while using sodium lactate Ringer's instead.

Researchers will compare the normal saline infusion group and sodium lactate Ringer's group to see if limiting the amount of normal saline infusion during emergency department can lower the incidence of acute kidney injury and mortality in patients with heat stroke.

Conditions

  • Heat Stroke

Interventions

DRUG

Normal Saline infusion and Ringer lactate infusion

The heat stroke patients will be infused with different chlorine concentrations fluid during the emergency department.

Sponsors & Collaborators

  • Yiwu Central Hospital

    collaborator OTHER

  • Jinhua People's Hospital

    collaborator OTHER

  • Jinhua Municipal Central Hospital

    collaborator OTHER

  • Dongyang People's Hospital

    collaborator OTHER

  • Lanxi People's Hospital

    collaborator OTHER

  • Second Affiliated Hospital, School of Medicine, Zhejiang University

    lead OTHER

Principal Investigators

  • Lan Chen, PHD · Second Affiliated Hospital, School of Medicine, Zhejiang University

Study Design

Allocation
NON_RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-05-28
Primary Completion
2025-10-31
Completion
2026-03-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05921695 on ClinicalTrials.gov