Genomics of Primary Sclerosing Cholangitis (PSC)
NCT01161992 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 1500
Last updated 2025-08-07
Summary
Primary Sclerosing Cholangitis (PSC) is a progressive liver disorder of unknown cause. Current evidence suggests that genes, the genetic material we inherit from our parents, in combination with environmental factors, likely play an important role in the development of PSC.
This study is being done to investigate whether genes make people more likely to develop PSC. Discovery of these genes will help us to better understand how PSC developes and subsequently, to apply new approaches for its prevention, diagnosis and treatment.
Conditions
- Primary Sclerosing Cholangitis (PSC)
Interventions
- GENETIC
-
Genetic Analysis
Perform Genome Wide Association Studies.
Sponsors & Collaborators
- lead OTHER
Principal Investigators
-
Konstantinos N Lazaridis, M.D. · Mayo Clinic
Eligibility
- Min Age
- 5 Years
- Max Age
- 90 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2002-03-31
- Primary Completion
- 2025-07-31
- Completion
- 2025-07-31
Countries
- United States
Study Locations
More Related Trials
-
Exome and Genome Analysis to Elucidate Genetic Etiologies and Population Characteristics in the Plain Community
NCT02927158 ·Status: RECRUITING
-
Genetic Analysis of Hereditary Prostate Cancer
NCT00001469 ·Status: COMPLETED
-
Genetic Testing and Phenotypic Characterization of Severely Obese Pediatric and Adult Volunteers
NCT02849977 ·Status: COMPLETED
-
Genetic Variants Associated With the Risk of Gall Stones and Cirrhosis.
NCT06679738 ·Status: NOT_YET_RECRUITING
-
Genetic Basis of Melanocytic Nevi
NCT03054584 ·Status: RECRUITING
-
Genetic Analysis of Gray Platelet Syndrome
NCT00069680 ·Status: COMPLETED
-
Implications of Maternal 45,X Mosaicism as a Secondary Genomic Finding Following Cell-Free DNA Sequencing During Pregnancy: A Deep Phenotype Study
NCT05548881 ·Status: WITHDRAWN
-
Adult Patients With Undiagnosed Conditions and Their Responses to Clinically Uncertain Results From Exome Sequencing
NCT03605004 ·Status: COMPLETED
-
Genetic Causes of FSGS, Nephrotic Syndrome, or Kidney Failure
NCT02194582 ·Status: ACTIVE_NOT_RECRUITING
-
Genetic Study of Patients With Primary Ciliary Dyskinesia
NCT00005650 ·Status: COMPLETED
-
Physicians' Understanding of Human Genetic Variation
NCT00339924 ·Status: COMPLETED
-
The Partners Genetics Collaborative Study of Schizophrenia
NCT00319904 ·Status: COMPLETED
-
Genetic and Metabolic Disease in Children
NCT02650622 ·Status: RECRUITING
-
Association of Genes to Resistance to Weight Loss in Obese Patients
NCT00858221 ·Status: COMPLETED
-
Identification of Mutations Responsible for Rare Familial Skin Diseases by Next Generation Sequencing
NCT02509650 ·Status: UNKNOWN
-
Study to Estimate How Common it is to Have Genetic Variants Associated With NAFLD
NCT04494360 ·Status: COMPLETED
-
Genetic Analysis of Psoriasis and Psoriatic Arthritis
NCT00341809 ·Status: COMPLETED
-
Genetics of Hepatitis C Virus Infection
NCT00005657 ·Status: COMPLETED
-
Study of Genotype and Phenotype in Patients With Alpha 1-Antitrypsin Deficiency
NCT00005098 ·Status: TERMINATED
-
Familial Myeloproliferative Disorders
NCT00666289 ·Status: COMPLETED
-
Genetic Studies of Lysosomal Storage Disorders
NCT00001215 ·Status: ENROLLING_BY_INVITATION
-
Gene Expression in Chronic Venous Leg Ulcers
NCT05134597 ·Status: UNKNOWN
-
Genetic Analysis of Uncommon Disease Presentations in Non-US Populations
NCT06595940 ·Status: RECRUITING
-
Genetic Analysis of Pheochromocytomas, Paragangliomas and Associated Conditions
NCT03160274 ·Status: RECRUITING
-
Analysis of Genes That Predispose People to Develop High Blood Pressure
NCT00522119 ·Status: COMPLETED