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Role of Donor Genetics and Recipient Genetics in Kidney Transplant Outcomes

NCT01143532 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 26

Last updated 2023-02-24

No results posted yet for this study

Summary

Background:

\- Genetic variation in a particular chromosome is a major contributor to the increased risk for kidney disease that is common in people of African descent, although the specific gene, mutations, and other aspects of the variations remain to be determined. By studying the outcomes of kidney transplant in donors and recipients of African descent, researchers hope to better understand the effects of this genetic variation on the success of kidney transplants.

Objectives:

\- To examine possible connections between genetic variations and kidney transplant outcomes for donors and recipients.

Eligibility:

* Participants in kidney transplant where both donor and recipient were of black African descent.
* Eligible transplants include both living donor and deceased donor.

Design:

* The study will involve one visit of up to 8 hours.
* All participants will provide a detailed personal and family medical history.
* All participants will provide blood and urine samples, including a 24-hour urine collection, to test kidney function and collect material for genetic testing.
* Donor participants will also have a magnetic resonance imaging (MRI) scan of their remaining kidney.

Conditions

Sponsors & Collaborators

  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    lead NIH

Principal Investigators

  • Jeffrey B Kopp, M.D. · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Eligibility

Min Age
18 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-08-12
Primary Completion
2015-10-19
Completion
2015-10-19

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01143532 on ClinicalTrials.gov