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The Role of Glucocorticoid Receptor SNPs in Receptor Function and Metabolic Disease

NCT01143493 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 278

Last updated 2019-12-04

No results posted yet for this study

Summary

Background:

\- Glucocorticoids are primary stress response hormones released from the adrenal gland when an individual is under stress. Chronic or ongoing elevation of these hormones due to prolonged stress or medical treatments can have numerous harmful effects. Researchers are interested in learning more about how these hormones affect cell growth, development, and death. To study glucocorticoid hormones, researchers plan to use the medication dexamethasone, which affects the parts of cells that respond to glucocorticoid hormones.

Objectives:

\- To study glucocorticoid stress hormones in healthy individuals before and after receiving dexamethasone.

Eligibility:

* Healthy individuals at least 18 years of age.
* Participants must not be using certain medications that may affect the dexamethasone test, including hormonal contraception, steroid-based drugs, and some antidepressants.

Design:

* This study will require an initial screening visit and a second study visit. The visits are estimated to require about 1 to 2 hours of participation over a period of up to 14 days.
* Participants will be screened at visit 1 with a full physical examination and medical history, and an initial blood sample for testing.
* For visit 2, participants will be asked to abstain from all food and drinks except for water for 12 hours before the appointment, and will take one tablet of dexamethasone 9 hours before the appointment.
* Participants will have a second blood sample taken during visit 2, and will receive a snack after the blood is drawn.

Conditions

  • Glucose Homeostasis
  • Protein Metabolism
  • Lipid Metabolism
  • Respiratory Function
  • Connective Tissue Metabolism

Sponsors & Collaborators

  • National Institute of Environmental Health Sciences (NIEHS)

    lead NIH

Principal Investigators

  • Stavros Garantziotis, M.D. · National Institute of Environmental Health Sciences (NIEHS)

Eligibility

Min Age
18 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-09-30
Primary Completion
2019-12-02
Completion
2019-12-02

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01143493 on ClinicalTrials.gov