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Effect of Functional Genetic Polymorphisms on Brain Morphology and Function

NCT01035723 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 221

Last updated 2019-12-16

No results posted yet for this study

Summary

Background:

\- New research on genetics and the human genome has helped to identify certain genes that affect specific parts of the brain, including the parts that may be involved in drug use and dependency. Researchers are interested in studying both genetic information and brain activity to better understand variations in brain function among individuals.

Objectives:

\- To study brain activity in conjunction with specific genetic information provided by healthy volunteers including smokers, non-smokers, people with drug dependence, and those who do not have any dependence on any substance.

Eligibility:

\- Healthy volunteers between 18 and 50 years of age.

Design:

* This is an 8 10 hour study which may be completed in 1, 2, or 3 visits.
* Participants will complete questionnaires about emotional and psychological responses to different situations, including stressful situations.
* Participants will have a training session in a mock (fake) scanner to practice tasks to be completed in the real scanner.
* Participants will have the following two types of magnetic resonance imaging (MRI) scans in one scan session of the brain:
* A structural MRI scan to provide basic information about each participant's brain.
* A functional MRI scanning session, in which participants will perform a memory task to provide information about brain activity.
* Participants will provide blood samples for research and testing....

Conditions

  • Drug Abuse

Sponsors & Collaborators

  • National Institute on Drug Abuse (NIDA)

    lead NIH

Principal Investigators

  • Elliot Stein, Ph.D. · National Institute on Drug Abuse (NIDA)

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2005-09-13
Completion
2013-02-25

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01035723 on ClinicalTrials.gov