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Determination of the Acute Effects of Aortic Stenosis on Coronary Artery Haemodynamics

NCT01118442 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 6

Last updated 2017-02-08

No results posted yet for this study

Summary

Narrowing of the main valve which controls blood leaving the heart leads to a marked increase in death. To overcome this narrowing the heart muscle thickens abnormally and contracts more vigorously. However, in doing so, blood flow patterns to the heart muscle change through mechanisms which are incompletely understood. New technology allows such heart valve blockages to be fixed using balloons and metal stents inserted through tubes placed in arteries in the leg. Using sensors placed in these tubes it is possible to make detailed measurements of coronary flow and pressure, and apply new mathematical techniques to allow a better understanding of the detrimental effects that aortic stenosis has on coronary flow, before and after valve surgery.

Conditions

  • Aortic Valve Stenosis

Sponsors & Collaborators

  • Imperial College London

    lead OTHER

Principal Investigators

  • Justin E Davies, MRCP PhD · Imperial College London

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-12-31
Primary Completion
2019-12-31
Completion
2019-12-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01118442 on ClinicalTrials.gov