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Vasodilator Free Measure of Fractional Flow Reserve

NCT01118481 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 157

Last updated 2017-02-07

No results posted yet for this study

Summary

Narrowing of coronary arteries interferes with blood flow and can cause chest pain. Cardiologists sometimes quantify the extent of the narrowing by measuring the fractional flow reserve (the ratio of the pressure in the aorta to the pressure downstream of the narrowing under conditions of maximal flow). We propose a new technique based on principles of wave intensity analysis (WIA) to better assess coronary stenosis and the significance of the narrowing without the need for administration of vasodilator agents such as adenosine. This would simplify assessment and improve our ability to advise patients whether stent treatment will help their symptoms.

Conditions

  • Coronary Stenosis

Sponsors & Collaborators

  • Hospital San Carlos, Madrid

    collaborator OTHER

  • Imperial College London

    lead OTHER

Principal Investigators

  • Justin E Davies, BSc, MBBS, MRCP, PhD · Imperial College London

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-01-31
Primary Completion
2011-06-30
Completion
2011-06-30

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01118481 on ClinicalTrials.gov