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Impact of Heart Failure on Calcium Homeostasis and Mitochondrial Function in Human Skeletal Muscle

NCT01014611 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 3

Last updated 2012-09-27

No results posted yet for this study

Summary

The aim of this project is to investigate the impact of heart failure (HF) on calcium homeostasis, mitochondrial function and oxidative stress in human skeletal muscle, before and after exercise training. The role playing by circulating factors such as cytokines and catecholamines will also be evaluated.

24 HF patients will be enrolled in the study: 12 class II NYHA HF volunteers with a fraction of ejection between 40% and 30 %, and 12 class III NYHA HF volunteers with a fraction of ejection lower than 30 %. They will be compared to 24 sedentary healthy volunteers, matched on age and physical activity.

Conditions

Sponsors & Collaborators

  • Ministry of Health, France

    collaborator OTHER_GOV

  • National Cancer Institute, France

    collaborator OTHER_GOV

  • Institut de Recherches Internationales Servier

    collaborator OTHER

  • Institut National de la Santé Et de la Recherche Médicale, France

    lead OTHER_GOV

Principal Investigators

  • Florence Galtier, MD · CHRU de Montpellier, France

  • Alain Lacampagne, PHD · INSERM, France

Eligibility

Min Age
35 Years
Max Age
65 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-04-30
Completion
2011-11-30

Countries

  • France

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01014611 on ClinicalTrials.gov