Resistance Training in HFpEF

Summary

The objective of this proposal is to determine the effect of resistance exercise training on locomotor muscle function, exercise capacity, exertional symptoms, and quality of life in HF patients with preserved ejection fraction (HFpEF).

Conditions

• Heart Failure Preserved Ejection Fraction

Interventions

OTHER

Resistance Exercise Training

1. Aerobic Exercise a. Each participant will engage in 5 minutes of aerobic based exercise on an arm/leg ergometer (NuStep Cross Trainer) at an intensity of 12-14 on the Borg Rating of Perceived Exertion Scale as a warm-up prior to the exercise session and again as a cool-down at the end of the exercise session. 2. Resistance Exercise - 2 sets of 8-12 repetitions - beginning at 60% of the initial 1 RM. a) Leg Extension, b) Bicep Curl, c) Leg Press, d) Chest Press, e) Leg Curl, f)Seated Row (horizontal or pulldown), g) Calf Raises 3. Core Strengthening Exercises a. 5-10 minutes of stability ball and balance exercises

RADIATION

DEXA bone scan

A DEXA scan that provides bone density measures.

OTHER

Cardiopulmonary Max Exercise Test

Pedaling on a cycle ergometer to volitional fatigue.

OTHER

Quality of Life Questionnaire

A 10 minute questionnaire that measures quality of life.

OTHER

Submaximal Exercise Test

Two short submaximal constant-load exercise sessions at 20 Watts. Each session will include 6 minutes of cycling (baseline). Following baseline, the sessions will be randomized to continued constant-load cycling for an additional 9 minutes (for echocardiographic measures) or randomized sub-systolic inflation of bilateral thigh pressure tourniquets to 40 and 80 mmHg for 3 minutes with 3 minutes of deflation between inflations to stimulate locomotor muscle neural feedback.

OTHER

Blood Draw

A blood draw amounting to 1 teaspoon of blood drawn.

Sponsors & Collaborators

• Mayo Clinic

  lead OTHER

Principal Investigators

• Thomas Olson, MS, PhD · Mayo Clinic

Study Design

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2015-06-30

Primary Completion

2021-01-31

Completion

2021-01-31

Countries

• United States

Study Locations