Resistance Exercise Program and Branched Chain Amino Acid Supplementation in Heart Failure Patients

Summary

Heart Failure (HF) is a complex syndrome which can include the physiological, neural hormonal and metabolic complications known as "Cardiac Cachexia" (CC). In the development of CC there is a release of catabolic cytokines (Tumor Necrosis Factor-α, interleukins 1 and 6)that cause a decrease of fat free mass and fat mass. These changes in body composition might be reversed with a therapeutic combination of resistance exercise and branched chain amino acid supplementation (BCAA). Thus the purpose of this study is evaluate changes in body composition after a resistance exercise program and BCAA supplementation in patients with HF.

Conditions

• Heart Failure

Interventions

DIETARY_SUPPLEMENT

RE and BCAA Supplementation

RE: Resistance Exercise BCAA: Branched Chain Aminoacids

OTHER

Resistance Exercise

Sponsors & Collaborators

• Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

  lead OTHER

Principal Investigators

• Juan A Pineda, MSc · Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

• Nestor A Sánchez, MSc · Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

• Lilia Castillo, PhD · Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

• Arturo Orea, MD · Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

• Rocio Cervantes, Ms · Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

• Keirns D Candace, MD · Massachusetts General Hospital Interpreter Services

• Carlos Ocampo, Mr · Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

• Karla Quiroz, Ms · Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

• Mónica Tenorio, Ms · Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

• Alberto Ronquillo, Mr · Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

Study Design

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2011-08-31

Primary Completion

2013-07-31

Completion

2013-08-31

Countries

• Mexico

Study Locations