Skeletal Muscle Dysfunction in Heart Failure

Summary

Patients suffering from congestive heart failure report reduced exercise capacity. This skeletal muscle dysfunction is also detectable when using small muscle groups which should not put any demand on the heart.

We hypothesize that congestive heart failure has systemic effects that causes the skeletal muscle dysfunction.

Conditions

• Heart Failure, Congestive

Interventions

BEHAVIORAL

One-knee extension ergometer

Sponsors & Collaborators

• Norwegian Health Association

  collaborator OTHER

• Norwegian School of Sport Sciences

  collaborator OTHER

• The Research Council of Norway

  collaborator OTHER

• University of Oslo

  collaborator OTHER

• Ullevaal University Hospital

  lead OTHER

Principal Investigators

• Ole M Sejersted, Professor · Institute for Experimental Medical Research, Ullevaal University Hospital

• Per Kristian B Lunde, Post Doc · Institute for Experimental Medical Research, Ullevaal University Hospital

• Ivar Sjaastad, Post Doc · Institute for Experimental Medical Research, Ullevaal University Hospital

• Jostein Hallen, Professor · Norwegian School of Sport Sciences

• Morten Munkvik, Ph.D student · Institute for Experimental Medical Research, Ullevaal University Hospital

• Tommy A Rehn, Vit.ass. · Institute for Experimental Medical Research, Ullevaal University Hospital

• Gunnar S Petersen, Ph.D student · Norwegian School of Sport Sciences

Study Design

Allocation

RANDOMIZED

Purpose

ECT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

40 Years

Max Age

78 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2005-03-31

Countries

• Norway

Study Locations