Genomic Structural Variation in Cancer Susceptibility
NCT00996710 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 1275
Last updated 2025-11-04
Summary
This study will look for new types of gene changes that may be related to cancer in some patients. Some gene changes (mutations) are passed on from parents to offspring (child). Other gene changes are new and are seen for the first time in a child. They are not seen in the parent.
Some of these gene changes may cause cancers in the offspring. We will look for gene changes by studying patients with cancer their parents and family members without cancer. In this study, we will be able to find gene changes that occur in the cancer patient but not in the rest of the family. Knowing the role that new gene changes play in cancer risk may help us find people at a higher risk of getting cancer.
Conditions
- Breast Cancer
- Colon Cancer
- Germ Cell Cancer
- Neuroblastoma
- Rectal Cancer
- Sarcoma
Sponsors & Collaborators
- collaborator OTHER
-
Coriell Institute
collaborator UNKNOWN -
Weill Medical College of Cornell University
collaborator OTHER -
University of Washington Center for Mendelian Genomics
collaborator UNKNOWN -
Memorial Sloan Kettering Cancer Center
lead OTHER
Principal Investigators
-
Zsofia Stadler, MD · Memorial Sloan Kettering Cancer Center
Eligibility
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2009-10-31
- Primary Completion
- 2026-10-31
- Completion
- 2026-10-31
Countries
- United States
Study Locations
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