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Discovering New Genetic Markers in Adults and Children Who May Be At Risk for Hereditary Forms of Cancer

NCT03922893 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1500

Last updated 2025-12-15

No results posted yet for this study

Summary

This study is being done to attempt to identify genetic mutations or other gene-based variations in adults and children who have cancer, or are likely to develop an inherited form of cancer, and potentially reduce their risk for cancer or treat the cancer earlier.

Conditions

Interventions

OTHER

Family History Information

The family history ascertainment focuses on self-reported family history of first-, second-, and third-degree family members, including types of malignancies/ pre-malignant lesions and age at diagnosis.

GENETIC

ORAGENE

Approximately 2-4mL of saliva may be collected in specialized Oragene DNA Self-Collection Kit tubes or buccal swab-based collection devices.

GENETIC

Blood

For select participants, 1-2 tubes of blood will be drawn for DNA and RNA analysis

OTHER

Skin Biopsy

In certain circumstances, for Memorial Sloan Kettering participants and their family members, it may be necessary to obtain a skin biopsy.

Sponsors & Collaborators

Principal Investigators

  • Kenneth Offit, MD, MPH · Memorial Sloan Kettering Cancer Center

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-04-17
Primary Completion
2029-04-30
Completion
2029-04-30

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03922893 on ClinicalTrials.gov