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Mechanisms of Increased Androgen Production Among Women With Polycystic Ovary Syndrome

NCT00989781 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 41

Last updated 2018-06-04

Study results available
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Summary

Jeffrey Chang MD is conducting a research study to learn more about the increased male hormone levels, otherwise known as androgens, seen in women with polycystic ovary syndrome (PCOS). Women with PCOS have ovaries that are comprised of many cysts, or follicles. They also have irregular or absent menstrual periods and symptoms of increased male hormones, such as facial hair or acne. In each part of the study (except part 4 which is for PCOS women only) we will be comparing responses of PCOS women to normal controls

Conditions

  • Polycystic Ovary Syndrome

Interventions

RADIATION

3-D Ultrasound

One time pelvic ultrasound

DRUG

recombinant human chorionic gonadotropin

Recombinant human chorionic gonadotropin will be given iv and blood samples obtained before and 24 hr afterwards

DRUG

Recombinant human follicle stimulating hormone

Recombinant human follicle stimulating hormone will be given iv and blood samples obtained before and 24 hr later.

DRUG

Adrenocorticotropin

Each subject will receive a 7 hr dose-response infusion of Adrenocorticotropin.

DRUG

Dexamethasone

Dexamethasone will be given prior to ACTH infusion test.

DRUG

Glucose

Each subject will undergo 3 oral glcuose tolerance tests.

Sponsors & Collaborators

Principal Investigators

  • R. Jeffrey Chang, M.D. · Professor

Study Design

Allocation
NON_RANDOMIZED
Purpose
SCREENING
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
37 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-09-30
Primary Completion
2013-09-30
Completion
2013-09-30

Countries

  • United States

Study Locations

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Entities

Drugs
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00989781 on ClinicalTrials.gov