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Canadian Varicocelectomy Initiative (CVI): Effects on Male Fertility and Testicular Function of Varicocelectomy

NCT00961558 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 300

Last updated 2012-05-28

No results posted yet for this study

Summary

A varicocele is the presence of dilated testicular veins in the scrotum. Although it is generally agreed that a varicocele is the most common identifiable pathology in infertile men (detected in up to 40% of men in some series of men with infertility), the influence of a varicocele on male fertility potential and role of varicocelectomy in restoring of fertility remain the subject of ongoing controversy. The present controversy on the effect of varicocelectomy on male fertility potential has led many clinicians to dismiss the diagnosis of a varicocele altogether and instead, offer alternative treatments to the couple. Many of these alternative therapies are expensive and risky for the patients and their children. Several recent reviews have critically examined the results of randomized, controlled trials of varicocelectomy on fertility potential. The effect of varicocelectomy on spontaneous pregnancy rates remains controversial.

The investigators hypothesize that a varicocelectomy will result in a significant improvement in fertility and testicular function in infertile men with a clinical varicocele.

Conditions

  • Male Infertility
  • Varicoceles

Interventions

PROCEDURE

Varicocelectomy

Varicocelectomy

Sponsors & Collaborators

Principal Investigators

  • Keith A Jarvi, MD · MOUNT SINAI HOSPITAL

  • Armand S Zini, MD · McGill University

  • Kirk C Lo, MD · MOUNT SINAI HOSPITAL

  • Ethan D Grober, MD · MOUNT SINAI HOSPITAL

  • Peter T Chan, MD · McGill University

  • John E Grantmyre, MD · Dalhousie University

  • Edward G Hughes, MD · McMaster University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
65 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Countries

  • Canada

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00961558 on ClinicalTrials.gov