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Effects of Intravenous Infusions of Gut Hormones on Appetite and Metabolism.

NCT00940134 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2012-06-15

No results posted yet for this study

Summary

The purpose of this study is to investigate the effects of intravenous infusion of two gastrointestinal hormones, PYY3-36 and GLP-1, alone and in combination, on appetite in healthy obese men. The investigators hypothesize that an intravenous infusion of each hormone alone will decrease food intake at a buffet meal and decrease appetite, and that in combination, there will be a greater decrease in food intake and appetite compared to each hormone alone.

Conditions

Interventions

BIOLOGICAL

PYY 3-36

0.8 pmol/kg/min x 3 hours

BIOLOGICAL

GLP-1

1.0 pmol/kg/min x 3 hours

BIOLOGICAL

saline infusion

saline infusion x 3 hours

Sponsors & Collaborators

  • University of Copenhagen

    lead OTHER

Principal Investigators

  • Nikolaj T Gregersen, MSc · University of Copenhagen

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-03-31
Primary Completion
2012-01-31
Completion
2012-01-31

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00940134 on ClinicalTrials.gov