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Degradation of the Anorexic Hormone Peptide YY

NCT02493959 · Status: COMPLETED · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 8

Last updated 2015-07-10

No results posted yet for this study

Summary

Peptide YY (PYY) is a gastrointestinal hormone released from the enteroendocrine cell upon food intake. The N-terminal truncated form, PYY3-36, exerts anorexic effects. In this study we want to investigate the kinetics of PYY1-36 and PYY3-36 and to examine whether a C-terminally degraded metabolite, PYY3-34, is formed after infusion of PYY.

Conditions

  • Healthy

Interventions

BIOLOGICAL

PYY1-36 infusion

Infusion of 1.6 pmol/kg/min PYY1-36 for 2 hrs.

BIOLOGICAL

PYY1-36 + sitagliptin

Infusion of 1.6 pmol/kg/min PYY1-36 for 2 hrs. Two doses of 100 mg sitagliptin are administered 10 and 1 hour before start of infusion, respectively.

BIOLOGICAL

PYY3-36 infusion

0.8 pmol/kg/min infusion of PYY3-36.

BIOLOGICAL

placebo

Infusion of saline for 2 hrs.

Sponsors & Collaborators

  • University of Copenhagen

    collaborator OTHER

  • Hvidovre University Hospital

    lead OTHER

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-05-31
Primary Completion
2015-07-31
Completion
2015-07-31

Countries

  • Denmark

Study Locations

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Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02493959 on ClinicalTrials.gov