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Oxyntomodulin, Mechanisms of Action in Relation to Appetite, Food Intake, Gastric Emptying and Energy Expenditure.

NCT01232244 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 15

Last updated 2013-12-10

No results posted yet for this study

Summary

Tiny molecules (hormones) are released from the bowels and other organs to the bloodstream in response to meals in order to orchestrate the metabolism. Oxyntomodulin, GLP-1 and glucagon are all known to regulate parameters such as appetite, food intake and induce weight loss.

Therefore we want to investigate mechanistic relations between the three hormones.

Conditions

Interventions

OTHER

GLP-1 infusion

1 pmol/kg/min

OTHER

Glucagon infusion

3ng/kg/min

OTHER

Oxyntomodulin infusion

3 pmol/kg/min

OTHER

GLP-1 and glucagon infusion

1 pmol/kg/min 3 ng/kg/min

OTHER

Placebo

NaCl 9 g/L infusion

Sponsors & Collaborators

  • University Hospital, Gentofte, Copenhagen

    lead OTHER

Principal Investigators

  • Jonatan I Bagger, MD · Gentofte University Hospital, University of Copenhagen

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-10-31
Primary Completion
2012-01-31
Completion
2012-01-31

Countries

  • Denmark

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01232244 on ClinicalTrials.gov