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Preoperative Accelerated Partial Breast Irradiation in Patients With Locally Recurrent or Second Primary Breast Cancer

NCT06362616 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 31

Last updated 2026-01-20

No results posted yet for this study

Summary

This study evaluates the acute toxicity and feasibility of repeat breast conserving therapy with preoperative accelerated partial breast re-irradiation (PAPBI) in female patients aged 51 years or older with ipsilateral recurrent or second primary low-risk breast cancer or DCIS.

Conditions

Interventions

RADIATION

Preoperative accelerated partial breast irradiation

Patients will be treated with 5 x 5.2 Gray (Gy) preoperative accelerated partial breast irradiation of the in situ tumor in the breast

PROCEDURE

Breast conserving surgery

Patients will be treated with breast conserving surgery.

PROCEDURE

Sentinel node procedure

Patients will undergo a (repeat) sentinel node procedure.

PROCEDURE

Biopsy track removal

The biopsy track will be surgically removed.

Sponsors & Collaborators

  • Medical Center Haaglanden

    collaborator OTHER

  • Erasmus Medical Center

    collaborator OTHER

  • The Netherlands Cancer Institute

    lead OTHER

Principal Investigators

  • Astrid Scholten, MD PhD · The Netherlands Cancer Institute

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
51 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-04-12
Primary Completion
2026-10-11
Completion
2027-04-11

Countries

  • Netherlands

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06362616 on ClinicalTrials.gov