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International Registry of Congenital Portosystemic Shunt (IRCPSS)

NCT06041906 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 500

Last updated 2025-06-18

No results posted yet for this study

Summary

Congenital Portosystemic Shunt (CPSS) is a rare condition important by the multiplicity and severity of associated complications.

CPSS is venous anomaly in which blood coming from the intestines only partially passes through the liver.

This leads to the accumulation of potentially toxic factors that cause systemic effects.

Complications vary among the individuals, and currently, it is challenging to predict which individuals will develop severe complications.

The IRCPSS registry is established with the aim of centralizing detailed clinical follow-up and biological information from participants around the world who suffer from Congenital Portosystemic Shunt (CPSS). A multidisciplinary consortium of experts is collaborating to enhance our understanding of the prevalence, natural history, individual risks, and physiopathology of the disease through the IRCPSS registry.

Conditions

  • Congenital Portosystemic Shunt
  • CPSS (Congenital Portosystemic Shunt)

Interventions

PROCEDURE

Shunt Closure

Consist in spontaneous, surgical or interventional closure of the shunt. Depending on context, surgical intervention may also be transplantation.

Sponsors & Collaborators

  • European Society of Pediatric Gastroenterology, Hepatology and Nutrition

    collaborator OTHER

  • European Association for the Study of the Liver (EASL)

    collaborator UNKNOWN

  • Fondation Andrea Ferrari

    collaborator UNKNOWN

  • Prof. Valérie Mc Lin

    lead OTHER

Principal Investigators

  • Valérie A Mc Lin, Prof. Dr. med. · University Hospital, Geneva

Eligibility

Min Age
1 Day
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-04-26
Primary Completion
2026-10-26
Completion
2028-12-31

Countries

  • United States
  • Australia
  • Belgium
  • Canada
  • France
  • Germany
  • Hungary
  • India
  • Israel
  • Italy
  • Japan
  • Netherlands
  • Spain
  • Switzerland
  • Turkey (Türkiye)
  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06041906 on ClinicalTrials.gov