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TSH Receptor Mutations Among a Consanguineous Community

NCT00747760 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 209

Last updated 2008-09-11

No results posted yet for this study

Summary

Resistance to thyrotropin (RTSH) is a condition of impaired responsiveness of the thyroid gland to TSH, characterized by elevated TSH, low or normal thyroid hormone levels, and hypoplastic or normal-sized thyroid gland.

The aim of the present study was to evaluate the clinical course over time,the genotype-phenotype association and the frequency of two different TSH-receptor (TSHR) mutations in a highly consanguineous population of the town of Um-El-Fahem.

Conditions

Sponsors & Collaborators

  • National Institutes of Health (NIH)

    collaborator NIH

  • HaEmek Medical Center, Israel

    lead OTHER

Principal Investigators

  • Yardena Tenenbaum-Rakover, MD · Ha'Emelk Medical Center,Afula, Israel

  • Samuel Refetoff, MD · The University of Chicago, Chicago, Il, USA

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2005-12-31
Primary Completion
2006-07-31
Completion
2006-12-31

Countries

  • United States
  • Israel

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00747760 on ClinicalTrials.gov