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Interrelations Between FT3, FT4 and Pituitary TSH

NCT01969552 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 1912

Last updated 2014-09-03

No results posted yet for this study

Summary

TSH plays a central role in current thyroid function testing both as a diagnostic tool and therapeutic target. Recent studies have suggested a more complex and hierarchical relationship between logTSH and FT4 over the entire functional spectrum than the widely assumed single log linear gradient (1-4). Our group has also shown a disjoint between pituitary TSH and FT3 serum levels being operative under conditions of levothyroxine monotherapy (5).

The present prospective observational study aims at confirming some of these findings and exploring additional factors other than TSH that may be important in shaping the interrelation of thyroid parameters and modulating thyroidal activity in health and disease.

To this purpose, unselected patients presenting for thyroid testing or treatment to a specialised unit at a teaching hospital will be prospectively studied to assess the interplay of FT3, FT4 and TSH under various conditions, and to evaluate various thyroidal and non-thyroidal influences, such as disease entity, thyroid volume, deiodinase activity, thyroid medication, surgery, radioiodine treatment, age, BMI, smoking on pituitary set-point and homeostatic equilibria.

Conditions

  • Thyroid

Sponsors & Collaborators

  • Klinikum Lüdenscheid

    lead OTHER

Principal Investigators

  • Rolf Larisch, Prof · Klinikum Lüdenscheid Department of Nuclear Medicine

  • Rudolf Hoermann, Prof · Klinikum Luedenscheid Department of Nuclear Medicine

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-07-31
Primary Completion
2014-06-30
Completion
2014-06-30

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01969552 on ClinicalTrials.gov