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Genetic Variants and Susceptibility to Diseases of Prematurity in Very Low Birth-Weight Infants

NCT00710112 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1100

Last updated 2026-01-26

No results posted yet for this study

Summary

The purpose of this study is to determine if sequence variations in genes involved in the development and function of vulnerable organs increases susceptibility to chronic lung disease (CLD) and other diseases affecting premature infants, such as necrotizing enterocolitis (NEC), sepsis, patent ductus arteriosus (PDA) and intraventricular hemorrhage (IVH). The study will also determine whether measurement of certain biomarkers in serum will identify infants who will develop these complications of prematurity. Previous studies from this institution and others have identified genetic variants in some genes, such as toll like receptor genes are associated with higher risk of CLD or NEC. The interaction of these variants with other gene variants that can influence the risk of these diseases remains unclear.

Conditions

Interventions

GENETIC

gene variations

comparing variations in genes in infants who develop chronic lung disease and other diseases of prematurity and those who do not.

Sponsors & Collaborators

  • Medical College of Wisconsin

    lead OTHER

Principal Investigators

  • G. Ganesh Konduri, MD · Medical College of Wisconsin

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-06-30
Primary Completion
2027-06-30
Completion
2028-06-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00710112 on ClinicalTrials.gov